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Inactivated tetanus toxin is a(n)


A) nucleic acid vaccine.
B) conjugated vaccine.
C) subunit vaccine.
D) toxoid vaccine.
E) inactivated whole-agent vaccine.

F) A) and D)
G) D) and E)

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Table 18.1 Antibody Titer  Day 1  Day 7 Day 14  Day 21  Patient A 00256512 Patient B 1282565121024 Patient C 0000 Patient D 128128128128\begin{array} { | l | l | l | l | l | } \hline & \text { Day 1 } & \text { Day } 7 & \text { Day 14 } & \text { Day 21 } \\\hline \text { Patient A } & 0 & 0 & 256 & 512 \\\hline \text { Patient B } & 128 & 256 & 512 & 1024 \\\hline \text { Patient C } & 0 & 0 & 0 & 0 \\\hline \text { Patient D } & 128 & 128 & 128 & 128 \\\hline\end{array} -In Table 18.1, who is most likely protected from the disease, as observed by the test results over time?


A) Patient A
B) Patient B
C) Patient C
D) Patient D

E) B) and C)
F) A) and C)

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Table 18.1 Antibody Titer  Day 1  Day 7 Day 14  Day 21  Patient A 00256512 Patient B 1282565121024 Patient C 0000 Patient D 128128128128\begin{array} { | l | l | l | l | l | } \hline & \text { Day 1 } & \text { Day } 7 & \text { Day 14 } & \text { Day 21 } \\\hline \text { Patient A } & 0 & 0 & 256 & 512 \\\hline \text { Patient B } & 128 & 256 & 512 & 1024 \\\hline \text { Patient C } & 0 & 0 & 0 & 0 \\\hline \text { Patient D } & 128 & 128 & 128 & 128 \\\hline\end{array} -In Table 18.1, who probably has the disease?


A) Patients A and C
B) Patients A and D
C) Patients B and C
D) Patients C and D
E) Patients A and B

F) C) and D)
G) A) and B)

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Western blotting uses antibodies to detect specific proteins in a mixture of proteins.

A) True
B) False

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Haemophilus capsule polysaccharide plus diphtheria toxoid is a(n)


A) inactivated whole-agent vaccine.
B) attenuated whole-agent vaccine.
C) conjugated vaccine.
D) subunit vaccine.
E) toxoid vaccine.

F) D) and E)
G) A) and E)

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In an immunodiffusion test to diagnose the fungal disease histoplasmosis, a patientʹs serum is placed in a well in an agar plate. In a positive test, a precipitate forms as the serum diffuses from the well and meets material diffusing from a second well. In this test process, what is the most likely identity of the material in the second well?


A) red blood cells
B) a purified fungal antigen
C) a purified protozoan antigen
D) antibodies
E) entire fungal cells

F) A) and B)
G) B) and D)

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In a vaccine preparation, the term ʺattenuatedʺ means that the agent does NOT replicate.

A) True
B) False

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A reaction that uses the absence of hemolysis of red blood cells to indicate an antigen antibody reaction is called a(n)


A) agglutination reaction.
B) complement fixation.
C) immunofluorescence.
D) neutralization reaction.
E) precipitation reaction.

F) A) and C)
G) None of the above

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The home pregnancy test kit is an example of a direct ELISA.

A) True
B) False

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True

Which of the following is NOT an advantage of live attenuated vaccine agents?


A) They occasionally revert to virulent forms.
B) They require few or no booster immunizations.
C) The immune response generated by the vaccine closely mimics a real infection.
D) They stimulate by cell-mediated and humoral immune responses.
E) They elicit lifelong immunity.

F) B) and E)
G) C) and E)

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A

Dead Bordetella pertussis can be used in a(n)


A) inactivated whole-agent vaccine.
B) attenuated whole-agent vaccine.
C) conjugated vaccine.
D) subunit vaccine.
E) toxoid vaccine.

F) A) and B)
G) B) and D)

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In an immunodiffusion test to diagnose histoplasmosis, a patientʹs serum is placed in a well in an agar plate. In a positive test, a line forms as the serum diffuses from the well and meets material diffusing from a second well. What type of test is this?


A) a precipitation reaction
B) a direct ELISA test
C) a complement-fixation test
D) an agglutination reaction
E) an indirect ELISA test

F) B) and D)
G) C) and D)

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A reaction between an antibody and soluble antigen-forming lattices is called a(n)


A) agglutination reaction.
B) complement fixation.
C) immunofluorescence.
D) neutralization reaction.
E) precipitation reaction.

F) A) and E)
G) A) and C)

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A patient shows the presence of antibodies against diphtheria toxin. Which of the following statements is FALSE?


A) A recent transfusion may have passively introduced the antibodies.
B) The patient may have had the disease and has recovered.
C) The patient may have the disease.
D) The patient may have been vaccinated.
E) The patient was near someone who had the disease.

F) A) and B)
G) A) and C)

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A reaction between antibody and particulate antigen is called a(n)


A) agglutination reaction.
B) complement fixation.
C) immunofluorescence.
D) neutralization reaction.
E) precipitation reaction.

F) A) and C)
G) A) and E)

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What type of vaccine involves host synthesis of viral antigens?


A) nucleic acid vaccine
B) attenuated whole-agent vaccine
C) conjugated vaccine
D) toxoid vaccine
E) subunit vaccine

F) A) and B)
G) None of the above

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A

An ELISA for Hepatitis C has 95 percent sensitivity and 90 percent specificity. This means that the test


A) detects 95 percent of the true positive samples and has 90 percent false positive results.
B) detects 5 percent of the true positive samples and has 90 percent false positive results.
C) detects 95 percent of the true positive samples and has 10 percent false positive results.
D) detects 5 percent of the true positive samples and has 10 percent false positive results.
E) detects 90 percent of the true positive samples and has 5 percent false positive results.

F) B) and C)
G) A) and E)

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A highly specific diagnostic test will be unlikely to indicate a positive result if a specimen being tested is a true negative.

A) True
B) False

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Design a serological test to detect botulinum toxin in food.

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Monoclonal antibodies are used in diagnostic tests and disease treatments because they


A) can be produced in large quantities.
B) are highly specific.
C) contain a mixture of antibodies.
D) are highly specific and they can be produced in large quantities.
E) are highly specific, they can be produced in large quantities, and they contain a mixture of antibodies.

F) None of the above
G) A) and B)

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