Question 1

DNA polymerases are unable to bind to what areas of the chromosome?

Accepted Answer

A)   Centromeres
B)   3' end of telomeres
C)   Origins of replicationD) A) and B)
E) All of the above

Question 2

The origin of replication in bacteria is called OriC.
TRUE

Accepted Answer

A) True 
 B)False

Question 3

Which of the following stops the replication of DNA in prokaryotes?

Accepted Answer

A)   Tus proteins
B)   DNA ligase
C)   Okazaki fragments
D)   The end of the chromosomeE) A) and B)
F) B) and D)

Question 4

The movement of the replication fork in bacterial replication is unidirectional.

Accepted Answer

A) True 
 B)False

Question 5

Responsible for the majority of DNA replication.

Accepted Answer

A)   DNA ligase
B)   DNA primase
C)   Topoisomerase
D)   DNA polymerase I
E)   DNA polymerase IIIF) A) and B)
G) B) and D)

Question 6

DNA polymerase III has an error in replication once every 100 million nucleotides.

Accepted Answer

A) True 
 B)False

Question 7

Prevents supercoiling ahead the replication fork.

Accepted Answer

A)   DNA ligase
B)   DNA primase
C)   Topoisomerase
D)   DNA polymerase I
E)   DNA polymerase IIIF) D) and E)
G) A) and B)

Question 8

What was the control in Arthur Kornberg's in vitro replication experiment described in this chapter?

Accepted Answer

A)   The use of radiolabeled nucleotide triphosphates
B)   The exclusion of template DNA in one test tube
C)   Adding perchloric acid
D)   The use of
E)   coli proteinsF) A) and D)
G) A) and B)

Question 9

The Meselson-Stahl experiments supported the model of dispersive DNA replication.

Accepted Answer

A) True 
 B)False

Question 10

DNA polymerase III is the main replication enzyme in prokaryotes. What is it in eukaryotes?

Accepted Answer

A)   DNA pol a
B)   DNA pol d
C)   DNA pol b
D)   DNA pol gE) None of the above
F) C) and D)

Question 11

Which of the following is a restriction placed on DNA polymerase?

Accepted Answer

A)   DNA polymerase can attach new nucleotides only in the 5' to 3' direction.
B)   DNA polymerases must begin synthesis using an RNA primer.
C)   DNA polymerases must have a template strand to copy from.
D)   All of the above are restrictions of DNA polymerase.E) B) and C)
F) All of the above

Question 12

Okazaki fragments do which of the following?

Accepted Answer

A)   Assist in forming the replication fork
B)   Bind to the oriC region
C)   Assist in the synthesis of DNA from the lagging strand
D)   Reform the double-helix following replication
E)   None of the answers are correctF) A) and B)
G) A) and C)

Question 13

What functions are accomplished by the primosome?

Accepted Answer

A)   Tracking along DNA
B)   Tracking along DNA, separating double stranded DNA
C)   Tracking along DNA, separating double stranded DNA, synthesizing RNA primers
D)   Tracking along DNA, separating double stranded DNA, synthesizing RNA primers, adding nucleotidesE) B) and C)
F) A) and D)

Question 14

Which of the following best describes the double-helix of DNA?

Accepted Answer

A)   It has directionality
B)   The strands are arranged in an anti-parallel arrangement
C)   The strands are complementary
D)   All of the answers are correctE) A) and D)
F) A) and C)

Question 15

Manufactures a 10-12 base segment of RNA.

Accepted Answer

A)   DNA ligase
B)   DNA primase
C)   Topoisomerase
D)   DNA polymerase I
E)   DNA polymerase IIIF) B) and E)
G) B) and C)

Question 16

The ability of the DNA polymerase to remove mismatched bases is called exonuclease cleavage
(proofreading).

Accepted Answer

A) True 
 B)False

Question 17

Replication usually begins in GC rich regions due to the presence of only 2 hydrogen bonds between
the bases.

Accepted Answer

A) True 
 B)False

Question 18

Which of the following is NOT a reason for the high fidelity of the newly synthesized DNA molecule?

Accepted Answer

A)   The hydrogen bonding between purines and pyrimidines is stable.
B)   The DNA polymerase is unlikely to form bonds between nucleotides if they are mismatched.
C)   The DNA polymerase has exonuclease functions.
D)   The DNA polymerase has the ability to change the structure of the base in order to form the correct bond.E) A) and C)
F) All of the above

Question 19

DNA helicase enzymes move in what direction along the DNA during DNA replication?

Accepted Answer

A)   5' to 3'
B)   3' to 5'
C)   They remain stationaryD) A) and B)
E) None of the above

Question 20

Synthesizes the lagging strand of the DNA.

Accepted Answer

A)   DNA ligase
B)   DNA primase
C)   Topoisomerase
D)   DNA polymerase I
E)   DNA polymerase IIIF) D) and E)
G) A) and D)

Exam 11: Dna Replication

DNA polymerase III is the main replication enzyme in prokaryotes. What is it in eukaryotes?

Correct AnswerverifiedShow Answer

The ability of the DNA polymerase to remove mismatched bases is called exonuclease cleavage (proofreading).

Correct AnswerverifiedShow Answer

Which of the following stops the replication of DNA in prokaryotes?

Correct AnswerverifiedShow Answer

The origin of replication in bacteria is called OriC. TRUE

Correct AnswerverifiedShow Answer

Responsible for the majority of DNA replication.

Correct AnswerverifiedShow Answer

Synthesizes the lagging strand of the DNA.

Correct AnswerverifiedShow Answer

Which of the following best describes the double-helix of DNA?

Correct AnswerverifiedShow Answer

Prevents supercoiling ahead the replication fork.

Correct AnswerverifiedShow Answer

The movement of the replication fork in bacterial replication is unidirectional.

Correct AnswerverifiedShow Answer

DNA helicase enzymes move in what direction along the DNA during DNA replication?

Correct AnswerverifiedShow Answer

What was the control in Arthur Kornberg's in vitro replication experiment described in this chapter?

Correct AnswerverifiedShow Answer

Manufactures a 10-12 base segment of RNA.

Correct AnswerverifiedShow Answer

Which of the following is NOT a reason for the high fidelity of the newly synthesized DNA molecule?

Correct AnswerverifiedShow Answer

Replication usually begins in GC rich regions due to the presence of only 2 hydrogen bonds between the bases.

Correct AnswerverifiedShow Answer

Which of the following is a restriction placed on DNA polymerase?

Correct AnswerverifiedShow Answer

What functions are accomplished by the primosome?

Correct AnswerverifiedShow Answer

DNA polymerases are unable to bind to what areas of the chromosome?

Correct AnswerverifiedShow Answer

DNA polymerase III has an error in replication once every 100 million nucleotides.

Correct AnswerverifiedShow Answer

The Meselson-Stahl experiments supported the model of dispersive DNA replication.

Correct AnswerverifiedShow Answer

Okazaki fragments do which of the following?

Correct AnswerverifiedShow Answer

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