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RANKL or receptor activators of nuclear factor kB


A) are receptors that bind directly to PTH.
B) are found on the surface of osteoclasts.
C) are molecules that cause osteoblasts to lay down bone.
D) is a signal molecule that stimulates osteoclasts development.
E) causes calcium to be excreted by the kidneys.

F) A) and C)
G) D) and E)

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The process by which osteoblasts add layers to circumferential lamellae is


A) appositional growth.
B) interstitial growth.
C) intramembranous growth.
D) endochondral ossification.
E) epiphyseal ossification.

F) A) and E)
G) C) and E)

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Calcitonin does all of the following except


A) increase bone deposition.
B) inhibit osteoclasts.
C) cause kidneys to excrete calcium.
D) cause less calcitriol to be secreted.
E) increase its level in pregnant women.

F) A) and E)
G) B) and D)

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Osteoclast-activating factor does all of the following except that it


A) is released in large amounts early in life.
B) increases the number of osteoclasts.
C) increases the activity of osteoclasts.
D) produces a severe osteoporosis.
E) is released by some cancer tumors.

F) A) and D)
G) B) and C)

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After a fracture of the diaphysis has healed, the thickened region that results is called the


A) epiphyseal plate.
B) external callus.
C) dense tuberosity.
D) condyle.
E) fracture facet.

F) B) and C)
G) B) and D)

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The following are major steps in the process of intramembranous ossification: 1) Clusters of osteoblasts form osteoid that becomes mineralized. 2) Osteoblasts differentiate within mesenchymal connective tissue. 3) Spicules of bone radiate out from the ossification centers. 4) Mesenchymal cells aggregate. What is the correct order for these events?


A) 4, 1, 2, 3
B) 2, 1, 3, 4
C) 4, 2, 1, 3
D) 2, 3, 1, 4
E) 3, 4, 2, 1

F) D) and E)
G) B) and C)

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In normal adult bones,


A) there is no turnover of minerals.
B) a portion of the protein and mineral content is replaced each year.
C) osteoblast activity exceeds osteoclast activity, once bone has been formed.
D) osteoclasts continue to be active long after osteoblast activity ceases.
E) exercise will have no effect on bone remodeling.

F) A) and D)
G) B) and C)

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Bones that are relatively long and slender, consisting of a shaft with two ends are


A) long bones.
B) flat bones.
C) sesamoid bones.
D) short bones.
E) irregular bones.

F) C) and E)
G) C) and D)

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Which of following is/are produced from the monocyte stem cells?


A) osteoblasts
B) osteoclasts
C) osteocytes
D) osteoprogenitor cells
E) osteogenic cells

F) A) and E)
G) B) and D)

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Parathyroid hormone functions in all of the following ways except


A) stimulating osteoclast activity.
B) increasing the rate of calcium absorption.
C) decreasing the rate of calcium excretion.
D) raising the level of calcium ion in the blood.
E) inhibiting calcitonin secretion.

F) C) and E)
G) B) and C)

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Which of the following is not true of osteocytes?


A) Osteocytes maintain protein and mineral content of matrix.
B) Osteocytes take part in repair of damaged bone.
C) Osteocytes form cytoplasmic extensions within canaliculi.
D) Osteocytes are located within lacunae.
E) Osteocytes have 50 or more nuclei.

F) A) and D)
G) A) and C)

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________ hormones stimulate osteoblasts to produce bone matrix.


A) Sex
B) Growth
C) Thyroid
D) Parathyroid
E) Pancreatic

F) C) and E)
G) B) and E)

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________ prevents damaging bone-to-bone contact within movable joints.


A) A synovial membrane
B) Elastic cartilage
C) A serous membrane
D) Articular cartilage
E) Serous fluid

F) D) and E)
G) B) and D)

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Suppose that epiphyseal lines appear in a 10-year-old's long bones. Which of the following statements is, therefore, true?


A) The epiphyseal plates have ossified and further growth in length is not possible.
B) Administration of growth hormone will stimulate future bone growth in length.
C) Osteoclasts will dissolve the metaphysis so length growth can continue until adulthood.
D) More growth will occur during the teenage years as sex hormones stimulate rebuilding of growth plates.
E) Intramembranous ossification will enable further growth in length.

F) B) and D)
G) A) and E)

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A child with rickets often has


A) oversized facial bones.
B) long fingers.
C) frequent bruises.
D) bowed legs.
E) inadequate muscle development.

F) C) and D)
G) All of the above

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Which of following is a function of the skeletal system?


A) body support
B) calcium homeostasis
C) protection of internal organs
D) blood cell production
E) All of the answers are correct.

F) D) and E)
G) C) and D)

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In-Text Figure Based Questions -Select the correct words for the following sentence: The (endosteum/periosteum) covers the superficial layerof compact bone and is made up of (the fibrous and cellular layers/osteoblasts, osteoclasts, and osteocytes) . (Figure 6-10)


A) periosteum; fibrous and cellular layers
B) endosteum; fibrous and cellular layers
C) periosteum; osteoblasts, osteoclasts, and osteocytes
D) endosteum; osteoblasts, osteoclasts, and osteocytes
E) endosteum and periosteum; osteoblasts, osteoclasts, and osteocytes

F) C) and E)
G) None of the above

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The femur can withstand ________ times the body's weight without breaking.


A) 3
B) 5 to 10
C) 8
D) 10 to 15
E) 30

F) B) and C)
G) C) and D)

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An open or ________ fracture projects through the skin.


A) external
B) exposed
C) complex
D) compound
E) complicated

F) A) and B)
G) A) and C)

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Which hormone increases calcium and phosphate ion absorption by the intestines?


A) parathyroid hormone
B) calcitriol
C) thyroxine
D) calcitonin
E) estrogen

F) A) and B)
G) B) and E)

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