Question 1

The purpose of the invariant chain (Ii,CD74) is to block the peptide-binding site of:

Accepted Answer

A)   antibody molecules
B)   class II molecules
C)   class I molecules
D)   T cell receptorsE) A) and C)
F) None of the above

Question 2

Antigens found in different species that trigger a similar antibody response are called:

Accepted Answer

A)   heterophile antigens
B)   haptens
C)   alloantigens
D)   autoantigensE) B) and C)
F) A) and B)

Question 3

If a determinant site on a molecule that stimulates antibody formation is produced by the folding of the primary chain,this is known as a:

Accepted Answer

A)   conformational epitope
B)   linear epitope
C)   hapten
D)   valenceE) B) and C)
F) B) and D)

Question 4

All of the following are characteristics of both MHC class I and class II molecules EXCEPT:

Accepted Answer

A)   expressed codominantly
B)   involved in antigen recognition
C)   members of the immunoglobulin superfamily
D)   expressed constitutively on all nucleated cellsE) None of the above
F) C) and D)

Question 5

The best immunogen would be:

Accepted Answer

A)   monovalent and genetically foreign
B)   less than 10,000 molecular weight
C)   multivalent with many specificities
D)   multivalent with one repeated specificityE) A) and B)
F) A) and C)

Question 6

Naturally occurring anti-A and anti-B antibodies are thought to be due to exposure to which of the following?

Accepted Answer

A)   heterophile antigens
B)   haptens
C)   alloantigens
D)   autoantigensE) B) and C)
F) A) and B)

Question 7

The use of an aluminum salt in the hepatitis vaccine is an example of a (an) :

Accepted Answer

A)   hapten
B)   adjuvant
C)   immunogen
D)   carrierE) A) and B)
F) A) and C)

Question 8

A substance used to enhance antibody formation is called a(n) :

Accepted Answer

A)   hapten
B)   adjuvant
C)   immunogen
D)   carrierE) A) and B)
F) A) and C)

Question 9

Which of the following is a characteristic of HLA-DR,-DP,and -DQ molecules?

Accepted Answer

A)   antigen receptors on all lymphocytes
B)   antigen receptors on T lymphocytes
C)   surface alloantigens on liver and kidney cells
D)   expressed co-dominantly (maternal and paternal) E) All of the above
F) C) and D)

Question 10

Which of the following is likely to be the most immunogenic?

Accepted Answer

A)   a lipid with a molecular weight of 50,000 d
B)   a polysaccharide with a molecular weight of 40,000 d
C)   a protein with a molecular weight of 45,000 d
D)   a nucleic acid with a molecular weight of 60,000 dE) A) and B)
F) C) and D)

Question 11

Class II molecules bind to what kind of peptides?

Accepted Answer

A)   native peptides
B)   processed exogenous
C)   processed endogenous
D)   any of the aboveE) None of the above
F) A) and C)

Question 12

If a patient's red cells agglutinate with anti-A reagent antibody and the serum agglutinates B cells,what is the blood type?

Accepted Answer

A)   type A
B)   type B
C)   type O
D)   cannot determineE) B) and C)
F) B) and D)

Question 13

Which best describes a finding of Landsteiner's study of haptens?

Accepted Answer

A)   Similar haptens trigger the same antibody response.
B)   Spatial configuration is recognized by antibody.
C)   Small chemical changes to a hapten do not affect antibody response.
D)   A hapten can react with many different antibodies.E) A) and B)
F) A) and C)

Question 14

HLA (MHC) class I protein is found on:

Accepted Answer

A)   RBCs
B)   all nucleated cells
C)   B cells and macrophages
D)   stem cells onlyE) C) and D)
F) A) and B)

Question 15

If a person has a reaction to poison ivy,this is due to:

Accepted Answer

A)   an autocoupling hapten
B)   a heterophile antigen
C)   a T-independent antigen
D)   use of an adjuvantE) B) and D)
F) None of the above

Question 16

Which of the following molecules is the better immunogen?

Accepted Answer

A)   protein
B)   protein polysaccharide
C)   nucleic acid
D)   lipidE) A) and B)
F) A) and C) A

Question 17

MHC class II antigens are recognized by which of the following cells?

Accepted Answer

A)   CD4+ T cells
B)   CD8+ T cells
C)   B cells
D)   macrophagesE) A) and B)
F) All of the above A

Question 18

A low-molecular-weight molecule that has one binding site for an antibody would be which of the following?

Accepted Answer

A)   antigen
B)   hapten
C)   immunogen
D)   valenceE) All of the above
F) B) and C)

Question 19

Which is characteristic of thymus-dependent antigens?

Accepted Answer

A)   They are proteins.
B)   They are mainly polysaccharides.
C)   They stimulate primarily IgM.
D)   all of the aboveE) None of the above
F) A) and D) A

Question 20

MHC class II molecules have specificity for:

Accepted Answer

A)   any endogenous peptide
B)   peptides with a particular motif
C)   one particular peptide
D)   native,conformational epitopesE) B) and C)
F) A) and D)

Exam 3: Nature of Antigens and Major Histocompatibility Complex

The purpose of the invariant chain (Ii,CD74) is to block the peptide-binding site of:

Correct AnswerverifiedShow Answer

Antigens found in different species that trigger a similar antibody response are called:

Correct AnswerverifiedShow Answer

If a determinant site on a molecule that stimulates antibody formation is produced by the folding of the primary chain,this is known as a:

Correct AnswerverifiedShow Answer

All of the following are characteristics of both MHC class I and class II molecules EXCEPT:

Correct AnswerverifiedShow Answer

The best immunogen would be:

Correct AnswerverifiedShow Answer

Naturally occurring anti-A and anti-B antibodies are thought to be due to exposure to which of the following?

Correct AnswerverifiedShow Answer

The use of an aluminum salt in the hepatitis vaccine is an example of a (an) :

Correct AnswerverifiedShow Answer

A substance used to enhance antibody formation is called a(n) :

Correct AnswerverifiedShow Answer

Which of the following is a characteristic of HLA-DR,-DP,and -DQ molecules?

Correct AnswerverifiedShow Answer

Which of the following is likely to be the most immunogenic?

Correct AnswerverifiedShow Answer

Class II molecules bind to what kind of peptides?

Correct AnswerverifiedShow Answer

If a patient's red cells agglutinate with anti-A reagent antibody and the serum agglutinates B cells,what is the blood type?

Correct AnswerverifiedShow Answer

Which best describes a finding of Landsteiner's study of haptens?

Correct AnswerverifiedShow Answer

HLA (MHC) class I protein is found on:

Correct AnswerverifiedShow Answer

If a person has a reaction to poison ivy,this is due to:

Correct AnswerverifiedShow Answer

Which of the following molecules is the better immunogen?

Correct AnswerverifiedA

MHC class II antigens are recognized by which of the following cells?

Correct AnswerverifiedA

A low-molecular-weight molecule that has one binding site for an antibody would be which of the following?

Correct AnswerverifiedShow Answer

Which is characteristic of thymus-dependent antigens?

Correct AnswerverifiedA

MHC class II molecules have specificity for:

Correct AnswerverifiedShow Answer

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