Question 1

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions
 
-A type of gene segment involved in somatic recombination events in Ig heavy chain and light chain as well as TCR a and b chain gene loci

Accepted Answer

C
Joining (J)segments are found in all antigen receptor loci.In the first somatic recombination event in Ig heavy chain and TCR $\beta$ chain loci,J segments are joined to D segments.In the only somatic recombination event in the Ig light chain and the TCR $\alpha$ chain loci,J segments are joined to V segments.

Question 2

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions
 
-A segment that encodes Ig domains that form part of the antigen-binding region of an Ig molecule

Accepted Answer

A
One variable (V)gene segment,from as many as 45 possible V gene segments,is used in each functional Ig heavy chain gene.This V gene segment encodes an Ig domain that includes complementarity-determining regions (CDRs)1 and 2 of the antigen-binding region of the heavy chain.

Question 3

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F) ?
-Pro-B cell to pre-B cell

Accepted Answer

A)  RAG-2
B)  Ikaros
C)  l5 surrogate light chain
D)  CD3e
E)  TAP-1F) Jak3G) All of the above
H) A) and B)

Question 4

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F) ?
-CD4+CD8+ thymocyte to single positive CD8+ thymocyte

Accepted Answer

A)  RAG-2
B)  Ikaros
C)  l5 surrogate light chain
D)  CD3e
E)  TAP-1F) Jak3G) D) and F)
H) All of the above

Question 5

Which of the following is NOT a required step in B and T lymphocyte maturation?

Accepted Answer

A)  Proliferative expansion of precursor cells
B)  Cell surface expression of complete antigen receptor complexes
C)  Positive selection
D)  Activation of precursors by foreign antigens
E)  Pre-antigen receptor expressionF) B) and D)
G) C) and E)

Question 6

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F) ?
-Stem cell to committed B or T lineage precursor

Accepted Answer

A)  RAG-2
B)  Ikaros
C)  l5 surrogate light chain
D)  CD3e
E)  TAP-1F) Jak3G) E) and F)
H) B) and C)

Question 7

Which of the following is NOT an example of a checkpoint in lymphocyte maturation that contributes to the selective maturation of cells with useful antigen receptors?

Accepted Answer

A)  B cell precursors that cannot express Ig g heavy chains die by apoptosis.
B)  T cell precursors that cannot express TCR b chains die by apoptosis.
C)  Immature B cells that bind to self antigen with high affinity die by apoptosis.
D)  Developing T cells that fail to express TCR a chains die by apoptosis.
E)  Developing T cells that recognize self major histocompatibility complex (MH
C)  molecules with high affinity die by apoptosis.F) C) and D)
G) A) and D)

Question 8

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions
 
-This type of gene segment that encodes part of the third complementarity determining region (CDR3)of Ig heavy chains and TCR b chains but not Ig light chains or TCR a chains

Accepted Answer

B
Diversity (D)segments are found in the...

Question 9

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions
 
-Encodes the isotype of antibodies made by naive B cells

Accepted Answer

D
Naive B cells produce IgM and IgD antibody isotypes.The IgM isotype is a characteristic of the heavy chain constant region,encoded by the C$\mu$ gene segment.

Question 10

Which of the following statements about negative selection during lymphocyte development is most accurate?

Accepted Answer

A)  The mechanism of negative selection is the death of cells whose antigen receptors are not stimulated by self antigens.
B)  The mechanism of negative selection is apoptosis actively induced by antigen-receptor recognition of self antigens.
C)  Negative selection ensures a self MHC restricted repertoire of T lymphocytes.
D)  Negative selection occurs only in T cell maturation and not in B cell maturation.
E)  The major mechanism of negative selection is inhibition of antigen receptor expression.F) A) and D)
G) A) and E)

Question 11

Which of the following is NOT a property of the V(D) J recombinase?

Accepted Answer

A)  Recognizes specific DNA sequences flanking gene segments in the antigen receptor gene loci
B)  Introduces double-stranded nicks in the DNA between recombination signal sequences and the adjacent V,D,or J coding sequences
C)  Promotes joining V-to-J,D-to-J,and V-to-D
D)  Repairs double-stranded DNA breaks
E)  Splices out intronic sequences from primary RNA transcriptsF) None of the above
G) A) and E)

Exam 6: Lymphocyte-Development

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions -A segment that encodes Ig domains that form part of the antigen-binding region of an Ig molecule

Correct Answer
verified
A One variable (V)gene segment,from as many as 45 possible V gene segments,is used in each functional Ig heavy chain gene.This V gene segment encodes an Ig domain that includes complementarity-determining regions (CDRs)1 and 2 of the antigen-binding region of the heavy chain.

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F) ? -Pro-B cell to pre-B cell

Correct Answer
verified

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F) ? -CD4+CD8+ thymocyte to single positive CD8+ thymocyte

Correct Answer
verified

Which of the following is NOT a required step in B and T lymphocyte maturation?

Correct Answer
verified

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F) ? -Stem cell to committed B or T lineage precursor

Correct Answer
verified

Which of the following is NOT an example of a checkpoint in lymphocyte maturation that contributes to the selective maturation of cells with useful antigen receptors?

Correct Answer
verified

Correct Answer
verified
B
Diversity (D)segments are found in the...
View Answer

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions -Encodes the isotype of antibodies made by naive B cells

Correct Answer
verified
D Naive B cells produce IgM and IgD antibody isotypes.The IgM isotype is a characteristic of the heavy chain constant region,encoded by the C\(\mu\) gene segment.

Which of the following statements about negative selection during lymphocyte development is most accurate?

Correct Answer
verified

Which of the following is NOT a property of the V(D) J recombinase?

Correct Answer
verified

Exam 6: Lymphocyte-Development

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions -A segment that encodes Ig domains that form part of the antigen-binding region of an Ig molecule

Correct AnswerverifiedA One variable (V)gene segment,from as many as 45 possible V gene segments,is used in each functional Ig heavy chain gene.This V gene segment encodes an Ig domain that includes complementarity-determining regions (CDRs)1 and 2 of the antigen-binding region of the heavy chain.

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F) ? -Pro-B cell to pre-B cell

Correct AnswerverifiedShow Answer

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F) ? -CD4+CD8+ thymocyte to single positive CD8+ thymocyte

Correct AnswerverifiedShow Answer

Which of the following is NOT a required step in B and T lymphocyte maturation?

Correct AnswerverifiedShow Answer

A block in the stage of lymphocyte development described in questions will be caused by a mutation in which of the genes listed (A-F) ? -Stem cell to committed B or T lineage precursor

Correct AnswerverifiedShow Answer

Which of the following is NOT an example of a checkpoint in lymphocyte maturation that contributes to the selective maturation of cells with useful antigen receptors?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedBDiversity (D)segments are found in the...View AnswerShow Answer

The figure depicts the germline organization of gene segments of the Ig heavy chain locus on chromosome 14.Choose the lettered label on the figure (A-E)that best matches the description in questions -Encodes the isotype of antibodies made by naive B cells

Correct AnswerverifiedD Naive B cells produce IgM and IgD antibody isotypes.The IgM isotype is a characteristic of the heavy chain constant region,encoded by the C\(\mu\) gene segment.

Which of the following statements about negative selection during lymphocyte development is most accurate?

Correct AnswerverifiedShow Answer

Which of the following is NOT a property of the V(D) J recombinase?

Correct AnswerverifiedShow Answer

Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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B
Diversity (D)segments are found in the...
View Answer

Correct Answer
verified
D Naive B cells produce IgM and IgD antibody isotypes.The IgM isotype is a characteristic of the heavy chain constant region,encoded by the C\(\mu\) gene segment.

Correct Answer
verified

Correct Answer
verified